Traditionally vitamin B12 has been used to treat pernicious anemia, however, more recently vitamin B12 supplementation has has been used in the treatment of various conditions related to sub-clinical deficiency of vitamin such as treatment to prevent memory loss, dementia, Alzheimer's disease, depression, poor concentration, reducing the signs of ageing, incontinence, asthma, allergies (such as in atopic allergy and eczema), amyotrophic lateral sclerosis (Lou Gehring's disease), vitiligo, ringing in the ears (tinitis), boosting energy, incontinence, lack of libido, male and female infertility, poor balance, hearing loss, and psoriasis.
High dose of hydroxocobalamin injected intravenously has been used for treatment of heavy metal poisoning and cyanide intoxication. High dose methyl cobalamin (injected) has been used to successfully treat the sign and symptoms of Alzheimer's disease.
Vitamin B12, either alone, or in combination with folate and vitamin B6, has also been used to reduce serum homocysteine levels, which have been associated with cardiovascular disease, vascular dementia and mild cognitive decline.
Deficiency of folate and particularly vitamin B12 can lead to an inability to properly process homocysteine, with the result that in many individuals who are deficient in these vitamins can have elevated levels of Hcy in both the serum and the brain. Elevated Hcy has been found to occur in 9-14% of people over 60 and has been correlated with an increased incidence/severity of cardiovascular disease and the development of mild cognitive impairment. High dose vitamin B12 supplementation in with folate and vitamin B6 has been shown to reduce the level of brain shrinkage in subjects with elevated serum homocysteine levels (Douaud etal, 2013, Smith etal, 2010). High dose intravenous methylcobalamin has been shown to reverse the symptoms of Alzheimer's disease (Ikeda etal, 1992).
It has been found that CFS/ME may be related to defects in either folate metabolism and/or the methylation cycle, as a high incidence of sufferers have genetic mutations in the MTHFR, MTR, MTRR, MTS and/or SHMT genes. In addition many CFS/ME individuals have genetically similar vitamin D receptor genes. It is possible that CFS/ME sufferers have had these "inborn errors of metabolism" for much of their life, without experiencing any significant problem until some precipitating event such as stress or a chronic infection has triggered chemical changes inside the body thereby resulting in CFS/ME. Many, many different treatments have been tried in an attempt to cure CFS/ME, with little success. Recently, however, it has been found that many people have obtained significant benefit from repeated dose treatment with high levels of vitamin D3, adenosylcobalamin and methylcobalamin. It is believed that this repeated high dose supplementation is required to stock both the body' methylcobalamin levels but also the adenosylcobalamin. Over time, and with the addition of high dose vitamin D supplementation the subjects appear to return to their pre-CFS status.
High dose treatment with methyl and adenosylcobalamin has been found to help reduce the pain in many people suffering sciatica and other types of neuropathic pain.
Hypothyroidism can lead to vitamin B12 deficiency. Persons with hypothyroidism should check their serum vitamin B12 levels..
Information on vitamin B12 deficiency can be found at the following sites
www.B12D.org : www.B12.com : www.vitaminb12deficiency.net.au http://b12awareness.org/
Pacholok, S.M. and Stuart, J. J. Could it be B12? An epidemic of misdiagnosis.
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